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GSK2983559 free acid
CAS No. 1579965-12-0
GSK2983559 free acid ( —— )
产品货号. M26238 CAS No. 1579965-12-0
GSK2983559 free Acid 是一种有效的选择性受体相互作用蛋白 2 (RIP2) 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥786 | 有现货 |
|
| 10MG | ￥1215 | 有现货 |
|
| 25MG | ￥2033 | 有现货 |
|
| 50MG | ￥3038 | 有现货 |
|
| 100MG | ￥4560 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GSK2983559 free acid
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GSK2983559 free Acid 是一种有效的选择性受体相互作用蛋白 2 (RIP2) 抑制剂。
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产品描述GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking many proinflammatory cytokine responses in human inflammatory bowel disease explant samples.
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体外实验GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells. Cell Viability Assay Cell Line:THP-1 cells Concentration:1-1024 nM Incubation Time:2 hours Result:Inhibited IL-8 production with an IC50 of 1.34 nM.
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体内实验GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse. Animal Model:C57BL/6 mice (female) injected with MDP (100 μg) Dosage:3 and 10 mg/kg Administration:Oral gavage; 3 and 10 mg/kg; once Result:Suppressed serum IL-6 levels in a dose-dependent manner.
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同义词——
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通路Others
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靶点Other Targets
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受体leucyl-tRNA synthetase| Ras-related GTP-binding protein D (RagD)
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研究领域——
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适应症——
化学信息
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CAS Number1579965-12-0
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分子量538.53
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分子式C21H23N4O7PS2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 5 mg/mL (9.28 mM)
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SMILESCC(C)(C)S(=O)(=O)c1cc2c(Nc3ccc4scnc4c3)ncnc2cc1OCCOP(O)(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Jong Hyun Kim, et al. Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction. Nat Commun. 2017 Sep 29;8(1):732.
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